Stereoselective syntheses of fluorescent non-natural aromatic amino acids based on asymmetric Michael additions.
نویسندگان
چکیده
Four fluorescent non-natural aromatic amino acids have been synthesized based on a key stereoselective Michael addition reaction. S-1-phenylethylamine was employed as both the source of amine and the stereoselectivity controller. The overall yields were moderate (30-50%). Fluorescent properties of some of the fluorophores were also investigated. It was found that compounds with a dimethylamino group bonded to the aromatic ring display intramolecular charge transfer fluorescence.
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ورودعنوان ژورنال:
- Molecules
دوره 12 5 شماره
صفحات -
تاریخ انتشار 2007